How does phenotypic screening work

Here's a good overview of phenotypic screening from a group at pfizer in science translational medicine.That got me to thinking about how i use the term, and to judge from the comments, there are at least two schools of thought on this.Death is a phenotype but because there are so many different ways of dying, it is not a very informative phenotype.Independently of the disease area (neurobiology, oncology, immunology, rare disease, metabolism, etc.), this approach allows validation of the relevant mechanism of action of drugs and/or.Zooming in, you can see we automatically detect the wells and the worms inside with enough resolution to quantify their behaviour in detail.

Recently, however, there appears to be renewed interest in reinventing phenotypic screens for lead discovery as a means of reenergizing drug discovery.For example, it can involve.The first says phenotypic to mean something like screening for some desired.This work includes designing hit identification strategies and screening funnels, developing assays for high.Here, we review success …

However, as the search for validated targets becomes more challenging and target space becomes increasingly competitive, alternative strategies, such as phenotypic drug discovery, are gaining favour.However, as the number of validated targets diminishes and the target space becomes increasingly competitive, alternative strategies, such as phenotypic screening, are gaining momentum.